Co-infection in patients with hypoxemic pneumonia due to COVID-19 in Reunion Island.

ABSTRACT: This study aimed to evaluate the incidence of co-infection with different types of pathogens in patients with hypoxemic pneumonia due to coronavirus disease 2019 (COVID-19) in Reunion Island.This observational study using a prospectively collected database of hypoxemic pneumonia due to COVID-19 cases was conducted at Félix Guyon University Hospital in Reunion Island, France.Between 18 March 2020 and 15 April 2020, 156 patients were admitted to our hospital for COVID-19. A total of 36 patients had hypoxemic pneumonia (23.1%) due to COVID-19. Thirty of these cases (83.3%) were imported by travelers returning mainly from metropolitan France and Spain. Patients were screened for co-infection with other pathogens at admission: 31 (86.1%) by multiplex polymerase chain reaction (PCR) and 16 (44.4%) by cytobacteriological examination of sputum culture. Five patients (13.9%) were found to have co-infection: 1 with influenza virus A H1N1 (pdm09) associated with Branhamella catarrhalis, 1 with Streptococcus pneumoniae associated with Haemophilus influenzae, 1 with Human Coronavirus 229E, 1 with Rhinovirus, and 1 with methicillin-susceptible Staphylococcus aureus. Patients with co-infection had higher D-dimer levels than those without co-infection (1.36 [1.34-2.36] µg/mL vs 0.63 [0.51-1.12] µg/mL, P = .05).The incidence of co-infection in our cohort was higher than expected (13.9%). Three co-infections (with influenza virus A(H1N1) pdm09, Streptococcus pneumoniae, and Staphylococcus aureus) required specific treatment. Patients with hypoxemic pneumonia due to COVID-19 should be screened for co-infection using respiratory cultures or multiplex PCR. Whilst our study has a number of limitations, the results from our study suggest that in the absence of screening, patients should be commenced on treatment for co-infection in the presence of an elevated D-dimer.

Delay discounting and under-valuing of recent information predict lower adherence to social distancing measures during the COVID-19 pandemic (preprint)

The COVID-19 pandemic has led to unprecedented changes in the day-to-day behaviours of populations globally, especially in areas where social distancing rules have been mandated. Understanding the cognitive mechanisms underlying (un)successful behaviour change around social distancing is crucial to inform public health policy for both the current and future crises.In this study, we utilise tasks probing delay discounting (the preference for immediate versus delayed rewards) and patch foraging (evaluating the trade-off between exploiting a known resource and exploring an unknown one) to investigate cognitive predictors of social distancing and mental health symptoms. Participants (N=442) were recruited from a large UK cohort (N=2025) nationally representative in age, gender and income.Greater sensitivity to reward magnitude during delay discounting predicted lower adherence to social distancing measures and higher levels of mood and anxiety symptoms. In addition, under-valuing recently sampled information during foraging separately predicted greater violation of social distancing. Analyses examining cognitive factors underpinning social distancing behaviour across two time points (early and late phases of the pandemic) additionally revealed that greater sensitivity to magnitude of rewards on offer during delay discounting predicted a greater decline in psychological inclination to maintain social distancing. Moreover, under-valuing recent information during foraging separately predicted less motivation to engage in social distancing during the established phase of the pandemic. The findings suggest that those who typically regulate their mood through behaviours that bring about immediate reward are also those who struggle to maintain social distancing. Further, those who adapt more quickly to new information showed better ability to change their behaviour in response to public health measures. These findings highlight the need for public health initiatives that bolster sustained confidence in planning around social distancing by emphasising the immediate rewards to self as well as longer term benefits.

A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island.

BACKGROUND: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. METHODS: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized to manage patients with COVID-19 in Reunion Island. RESULTS: Over the study period, 164 out of 398 patients (41.2%) infected with COVID-19 were admitted to Félix Guyon University Hospital. Of these, 36 (22%) developed hypoxemic pneumonia. Patients with hypoxemic pneumonia were aged 66 [56-77] years, 69% were male and 33% had hypertension. Ten patients (27.8%) were hospitalized in intensive care unit (ICU). Hydroxychloroquine/azithromycin treatment was associated with a lower ICU admission rate (P=0.008). None of the 6 patients treated with corticosteroids were hospitalized in ICU (P=0.16). There were no deaths at follow up (minimum 80 days). CONCLUSIONS: Despite the risk profile of COVID-19 patients with severe hypoxemic pneumonia, the mortality rate of the disease in Reunion Island was 0%. This may be due to the care bundle used in our hospital (early hospitalisation, treatment with hydroxychloroquine/azithromycin and/or corticosteroids, non-invasive respiratory support, etc).